{"id":82567,"date":"2024-08-27T10:27:00","date_gmt":"2024-08-27T07:27:00","guid":{"rendered":"https:\/\/new.mavikadin.com\/?p=82567"},"modified":"2024-09-17T20:05:54","modified_gmt":"2024-09-17T17:05:54","slug":"anti-tpo-yuksekligi-nedir-kan-testinde-tpo-yuksek-ciksa-ne-olur","status":"publish","type":"post","link":"https:\/\/www.tgrthaber.com\/mavikadin\/anti-tpo-yuksekligi-nedir-kan-testinde-tpo-yuksek-ciksa-ne-olur\/","title":{"rendered":"Anti TPO y\u00fcksekli\u011fi nedir? Kan testinde TPO y\u00fcksek \u00e7\u0131ksa ne olur?"},"content":{"rendered":"

Tiroid peroksidaz (TPO), tiroid bezinde yer alan, troid hormonlar\u0131n\u0131n \u00fcretiminde etkili olan bir enzimdir. Anti-TPO antikorlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizin tiroid bezinde bulunan tiroid peroksidaz enzimlerini hedef almas\u0131 ve yanl\u0131\u015fl\u0131kla sald\u0131rmas\u0131 sonucu meydana gelir. Anti TPO y\u00fcksekli\u011fi \u00e7o\u011fu zaman Hashimoto tiroiditi ve Graves hastal\u0131\u011f\u0131 gibi otoimm\u00fcn tiroid hastal\u0131klar\u0131na ba\u011fl\u0131 ortaya \u00e7\u0131kar.<\/p>\n

Tiroid peroksidaz otoantikor testi olarak da bilinen Anti-TPO testi, kandaki TPO antikorlar\u0131n\u0131n seviyesini te\u015fhis etmek i\u00e7in kullan\u0131l\u0131r. TPO, tiroid bezinin \u00fcretti\u011fi bir enzim olan tiroid peroksidaz demektir. Troid bezi, boyun taban\u0131nda, Adem elmas\u0131n\u0131n hemen alt\u0131nda, yemek borusunun \u00f6n\u00fcnde bulunan kelebek \u015feklinde organd\u0131r. Troid bezleri hormon \u00fcretimi, metabolizma h\u0131z\u0131n\u0131 d\u00fczenlemek, v\u00fccut s\u0131cakl\u0131\u011f\u0131n\u0131n dengelenmesi, b\u00fcy\u00fcme, geli\u015fme, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve i\u015ftah\u0131n kontrol\u00fc gibi pek \u00e7ok vazifede rol alan troid hormonlar\u0131 \u00fcretir.  Anti TPO, \u00e7e\u015fitli hastal\u0131klar nedeniyle y\u00fckselen bir v\u00fccut bile\u015fenidir. Anti TPO y\u00fcksekli\u011fi genellikle Hashimoto hastal\u0131\u011f\u0131 ve Graves hastal\u0131\u011f\u0131 sonucu meydana gelir.<\/p>\n

ANT\u0130 TPO NORMAL DE\u011eER\u0130 NED\u0130R?<\/strong><\/h3>\n

Anti TPO\u2019nun normal de\u011fer aral\u0131\u011f\u0131 0-9 IU\/ml\u2019dir. (Bir mililitrede 0-9 uluslararas\u0131 ge\u00e7erlik ta\u015f\u0131yan birim). Bu de\u011fer aral\u0131\u011f\u0131 laboratuvardan laboratuvara hafif de\u011fi\u015fiklik g\u00f6sterebilmektedir. Test sonucunu yorumlayacak ki\u015fi doktorunuzdur.<\/p>\n

ANT\u0130-TPO Y\u00dcKSEKL\u0130\u011e\u0130 NEDEN OLUR?<\/strong><\/h3>\n

Anti TPO, v\u00fccudun kendi \u00fcretti\u011fi yap\u0131lar\u0131 yok eden antikorlard\u0131r. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemimiz sa\u011fl\u0131kl\u0131 tiroid bezi h\u00fccrelerini ve tiroid hormonlar\u0131n\u0131 yanl\u0131\u015fl\u0131kla d\u00fc\u015fman olarak g\u00f6r\u00fcp sald\u0131rd\u0131\u011f\u0131nda, kandaki Anti TPO seviyesinde y\u00fckselme meydana gelir.<\/p>\n

Anti TPO y\u00fcksekli\u011finin en s\u0131k kar\u015f\u0131la\u015f\u0131lan nedeni hashimoto hastal\u0131\u011f\u0131d\u0131r. Hashimoto, tiroid bezinin iltihab\u0131d\u0131r, troid bezlerinin tiroid \u00fcretimini azaltmas\u0131na ba\u011fl\u0131 bu hastal\u0131k ortaya \u00e7\u0131kar.<\/p>\n

Frontiers in Immunology\u2019de 2017 May\u0131s ay\u0131ndaki 8. ciltte ge\u00e7en, Dr. Eleonore Fr\u00f6hlich ve Dr. Richard Wahl taraf\u0131ndan yap\u0131lan \u00e7al\u0131\u015fmaya g\u00f6re Anti-TPO antikorlar\u0131 Hashimoto hastal\u0131\u011f\u0131 olan ki\u015filerin yakla\u015f\u0131k %90’\u0131nda, Graves hastal\u0131\u011f\u0131 olan ki\u015filerin %75’inde ve tiroid kanseri olan ki\u015filerin ise %10 ila %20’sinde de bulunur.<\/p>\n

\"\"<\/p>\n

Anti TPO y\u00fcksekli\u011finin di\u011fer nedenleri ise \u015f\u00f6yle:<\/strong><\/h3>\n
    \n
  • Graves Hastal\u0131\u011f\u0131 (tiroid hormonlar\u0131n\u0131n a\u015f\u0131r\u0131 \u00fcretimi)<\/li>\n
  • \u0130diyopatik Miks\u00f6dem (tiroid hormonlar\u0131n\u0131n ciddi derecede d\u00fc\u015f\u00fck \u00fcretimi).<\/li>\n
  • Tiroid kanseri<\/li>\n
  • Enfeksiyona maruz kalma<\/li>\n
  • Y\u00fcksek iyot seviyeleri<\/li>\n
  • Otoimm\u00fcn hemolitik anemi<\/li>\n
  • Gran\u00fclomat\u00f6z tiroidit<\/li>\n
  • Zehirli olmayan nod\u00fcler guatr<\/li>\n
  • Romatoid artrit<\/li>\n
  • Sj\u00f6gren hastal\u0131\u011f\u0131 (G\u00f6zya\u015f\u0131 ve t\u00fck\u00fcr\u00fck bezlerine gelen hasarla birlikte a\u011f\u0131z ve g\u00f6z kurulu\u011funa neden olan bir hastal\u0131k)<\/li>\n
  • Sistemik Lupus Eritematozus<\/li>\n
  • \u0130ntrauterin bebek \u00f6l\u00fcm\u00fc (Anne karn\u0131nda, rahimde bebek \u00f6l\u00fcm\u00fc)<\/li>\n
  • Hamilelik<\/li>\n
  • Gebelik kaynakl\u0131 hipertansiyon<\/li>\n
  • D\u00fc\u015f\u00fck yapma<\/li>\n
  • Aile \u00f6yk\u00fcs\u00fc (ailede birinde bu sorun varsa sizde de g\u00f6r\u00fclebilir)<\/li>\n
  • Preeklampsi (Gebelik zehirlenmesi)<\/li>\n
  • Permat\u00fcre do\u011fum (Erken do\u011fum)<\/li>\n
  • Romatolojik hastal\u0131klar (Lupus, romatoid artrit)<\/li>\n
  • Romatoid artrit (Eklem iltihab\u0131)<\/li>\n
  • Lupus (Eklem a\u011fr\u0131lar\u0131na, y\u00fcksek ate\u015fe ve cilt sorunlar\u0131na neden olan bir hastal\u0131k)<\/li>\n
  • Ba\u015far\u0131s\u0131z t\u00fcp bebek giri\u015fimi<\/li>\n<\/ul>\n

    Ayr\u0131ca, Anti-TPO antikorlar\u0131, otoimm\u00fcn tiroid bozukluklar\u0131nda s\u0131k kar\u015f\u0131la\u015f\u0131lan bir durumdur, JAMA’da Haziran 2021’deki ara\u015ft\u0131rmaya g\u00f6re kad\u0131nlarda erkeklere k\u0131yasla bu antikorlar daha y\u00fcksek seviyelerde g\u00f6r\u00fcl\u00fcyor.<\/p>\n

    ANT\u0130-TPO Y\u00dcKSEKL\u0130\u011e\u0130 BEL\u0130RT\u0130LER\u0130 NELERD\u0130R?<\/strong><\/h3>\n

    yashodahospitals.com’un haberine g\u00f6re Anti-TPO y\u00fcksekli\u011finde \u015fu belirtiler g\u00f6r\u00fclebiliyor:<\/p>\n

      \n
    • Halsizlik<\/li>\n
    • \u0130stemeden kilo al\u0131m\u0131<\/li>\n
    • Cilt ve sa\u00e7 kurulu\u011fu<\/li>\n
    • Adet d\u00fczensizli\u011fi<\/li>\n
    • Libidodada azalma<\/li>\n
    • Depresyon ve ruh hali de\u011fi\u015fimleri.<\/li>\n
    • So\u011fu\u011fa kar\u015f\u0131 hassasiyet<\/li>\n
    • Kab\u0131zl\u0131k<\/li>\n<\/ul>\n

      Ancak baz\u0131 ki\u015filerde Anti-TPO y\u00fcksekli\u011finde herhangi belirti g\u00f6r\u00fclmeyebiliyor.<\/p>\n

      ANT\u0130 TPO Y\u00dcKSEKL\u0130\u011e\u0130 NASIL D\u00dc\u015eER?<\/strong><\/h3>\n

      Anti TPO y\u00fcksekli\u011finin tedavisinde \u00e7ok y\u00f6nl\u00fc bir yakla\u015f\u0131m gereklidir. Sigara, baz\u0131 ila\u00e7lar Anti-TPO y\u00fcksekli\u011fi yap\u0131yorsa bu tetikleyicilerden uzak durmal\u0131d\u0131r.<\/p>\n

      Ya\u015fam Tarz\u0131 De\u011fi\u015fikleri: Sa\u011fl\u0131kl\u0131 beslenmeli, d\u00fczenli egzersiz yapmal\u0131, uyku saatlerine dikkat etmeli, stresten uzak durmal\u0131.<\/p>\n

      \u0130la\u00e7lar: Tiroid hormon d\u00fczeylerini d\u00fczenlemek ve otoimm\u00fcn yan\u0131t\u0131 bask\u0131lamak i\u00e7in doktorun re\u00e7ete edece\u011fi ila\u00e7lar\u0131 d\u00fczenli olarak kullanmal\u0131.<\/p>\n

      \"\"<\/p>\n

      ANT\u0130 TPO Y\u00dcKSEKL\u0130\u011e\u0130 KA\u00c7 OLURSA TEHL\u0130KEL\u0130D\u0130R?<\/strong><\/h3>\n

      Anti-TPO seviyesi 9 IU\/mL’den fazlaysa, y\u00fcksek kabul edilir, bu durum Hashimoto hastal\u0131\u011f\u0131 veya Graves hastal\u0131\u011f\u0131 gibi hastal\u0131klara i\u015fare edebilir.<\/p>\n

      ANT\u0130-TPO Y\u00dcKSEKL\u0130\u011e\u0130 B\u0130TK\u0130SEL TEDAV\u0130S\u0130<\/strong><\/h3>\n

      Anti TPO y\u00fcksekli\u011fi troid bezlerinin \u00e7al\u0131\u015fmas\u0131na zarar vererek hipotiroidi denilen tiroid tembelle\u011fine yol a\u00e7abiliyor. Prof. Dr. \u0130brahim Sara\u00e7o\u011flu hem hipotiroid (tiroidin yava\u015f \u00e7al\u0131\u015fmas\u0131) hem de hipertiroid (tiroidin h\u0131zl\u0131 \u00e7al\u0131\u015fmas\u0131) tedavisi i\u00e7in dereotu t\u00fcketimini \u00f6neriyor.<\/p>\n

      ANT\u0130 TPO TEST\u0130 NEDEN YAPILIR?<\/strong><\/h3>\n

      Anti-TPO testinin ba\u015fl\u0131ca kullan\u0131m alanlar\u0131 \u015funlard\u0131r:<\/p>\n

        \n
      • Otoimm\u00fcn Tiroid Hastal\u0131klar\u0131n\u0131n Te\u015fhisi: Anti-TPO testi, Hashimoto tiroiditi ve Graves hastal\u0131\u011f\u0131 gibi troid hastal\u0131klar\u0131n\u0131n te\u015fhisinde s\u0131kl\u0131kla kullan\u0131l\u0131r.<\/li>\n
      • Tiroid Hastal\u0131klar\u0131n\u0131n Takibi: Troid hastal\u0131klar\u0131n\u0131n takibi, hastal\u0131\u011f\u0131n seyri ve tedavinin nas\u0131l gitti\u011fine bakmak i\u00e7in de bu test uygulanabilir.<\/li>\n
      • K\u0131s\u0131rl\u0131\u011f\u0131n De\u011ferlendirilmesi: Anti-TPO y\u00fcksekli\u011fi k\u0131s\u0131rl\u0131k olarak da belirti verebiliyor. Bu antikorlar\u0131n test edilmesi, k\u0131s\u0131rl\u0131k te\u015fhisinde rol oynayabilmektedir.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Tiroid peroksidaz (TPO), tiroid bezinde yer alan, troid hormonlar\u0131n\u0131n \u00fcretiminde etkili olan bir enzimdir. Anti-TPO antikorlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizin tiroid bezinde bulunan tiroid peroksidaz enzimlerini hedef almas\u0131 ve yanl\u0131\u015fl\u0131kla sald\u0131rmas\u0131 sonucu meydana gelir. Anti TPO y\u00fcksekli\u011fi \u00e7o\u011fu zaman Hashimoto tiroiditi ve Graves hastal\u0131\u011f\u0131 gibi otoimm\u00fcn tiroid hastal\u0131klar\u0131na ba\u011fl\u0131 ortaya \u00e7\u0131kar. Tiroid peroksidaz otoantikor testi olarak da […]<\/p>\n","protected":false},"author":30,"featured_media":82566,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"footnotes":""},"categories":[1991],"tags":[55309,2139],"class_list":["post-82567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-anti-tpo-tpo-yuksekligi-hasimato-graves-hastaligi-tiroid-testi","tag-troid"],"_links":{"self":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/82567"}],"collection":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/comments?post=82567"}],"version-history":[{"count":1,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/82567\/revisions"}],"predecessor-version":[{"id":82568,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/82567\/revisions\/82568"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/media\/82566"}],"wp:attachment":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/media?parent=82567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/categories?post=82567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/tags?post=82567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}