{"id":98665,"date":"2024-11-27T16:12:31","date_gmt":"2024-11-27T13:12:31","guid":{"rendered":"https:\/\/www.tgrthaber.com\/mavikadin\/?p=98665"},"modified":"2024-11-28T11:08:42","modified_gmt":"2024-11-28T08:08:42","slug":"b12-yuksekligi-nedenleri-belirtileri-ve-tedavisi-yuksek-b12-seviyesi-olum-riskini-artiriyor","status":"publish","type":"post","link":"https:\/\/www.tgrthaber.com\/mavikadin\/b12-yuksekligi-nedenleri-belirtileri-ve-tedavisi-yuksek-b12-seviyesi-olum-riskini-artiriyor\/","title":{"rendered":"B12 y\u00fcksekli\u011fi nedeni nedir? B12 y\u00fcksekli\u011fi belirtileri ve tedavisi! Y\u00fcksek b12 seviyesi \u00f6l\u00fcm riskini art\u0131r\u0131yor"},"content":{"rendered":"

V\u00fccut fonksiyonlar\u0131n\u0131n yerine getirilebilmesi i\u00e7in b12 vitamini elzem vitaminlerdendir. B12 vitamini normalde v\u00fccutta depolanmaz, kullan\u0131lmad\u0131\u011f\u0131nda idrarla at\u0131l\u0131r. Ancak karaci\u011fer hastal\u0131klar\u0131, b\u00f6brek yetmezli\u011fi, enfeksiyonlar, otoimm\u00fcn hastal\u0131klar, y\u00fcksek dozda b12 vitamini takviyesi almak ve l\u00f6semi gibi kanser t\u00fcrleri v\u00fccutta b12 vitaminin birikmesine ve b12 y\u00fcksekli\u011fine yol a\u00e7abiliyor.<\/p>\n

B12 NORMAL DE\u011eER\u0130 NED\u0130R?<\/h3>\n

MedlinePlus’a g\u00f6re b12 normal referans aral\u0131\u011f\u0131 160 ila 950 pikogram (pg\/mL) aras\u0131ndad\u0131r. Normal de\u011fer aral\u0131klar\u0131 laboratuvarlar aras\u0131nda biraz farkl\u0131l\u0131k g\u00f6sterebiliyor.<\/p>\n

B12 Y\u00dcKSEKL\u0130\u011e\u0130 NEDEN OLUR?<\/h3>\n

An International Journal of Medicine\u2019da 950 pg\/ml’nin \u00fcst\u00fc bir de\u011fer b12 y\u00fcksekli\u011fi olarak tan\u0131mlanmaktad\u0131r. B12 y\u00fcksekli\u011fi (hiperkobalaminemi), b12 i\u00e7eren besinlerin fazla t\u00fcketilmesi, b12 takviyelerinin uzun s\u00fcre kullan\u0131lmas\u0131n\u0131n yan\u0131 kan kanseri, karaci\u011fer hastal\u0131klar\u0131, alkolizm gibi durumlardan da kaynaklanabiliyor.<\/p>\n

\"b12<\/p>\n

B12 y\u00fcksekli\u011fine yol a\u00e7abilen ba\u015fl\u0131ca nedenler \u015f\u00f6yledir:<\/p>\n

Karaci\u011fer Hastal\u0131klar\u0131:<\/strong> Karaci\u011fer hasar\u0131 veya siroz gibi karaci\u011fer hastal\u0131klar\u0131<\/p>\n

Miyeloproliferatif Bozukluklar:<\/strong> L\u00f6semi ve polisitemi vera gibi kan h\u00fccrelerinin \u00fcretimini etkileyen hastal\u0131klar.<\/p>\n

B\u00f6brek Yetmezli\u011fi:<\/strong> B\u00f6brek fonksiyonlar\u0131n\u0131n bozulmas\u0131, b\u00f6brek yetmezli\u011fi<\/p>\n

B12 Takviyelerinin A\u015f\u0131r\u0131 Kullan\u0131m\u0131:<\/strong> Y\u00fcksek dozda B12 takviyeleri almak<\/p>\n

Hipertiroidizm:<\/strong> Tiroid bezinin a\u015f\u0131r\u0131 \u00e7al\u0131\u015fmas\u0131.<\/p>\n

Romatolojik Hastal\u0131klar:<\/strong> SLE, Romatoid artirit, vb.<\/p>\n

Kanser Hastal\u0131\u011f\u0131:<\/strong> Karaci\u011fer, meme, ba\u011f\u0131rsak vb kanser hastal\u0131klar\u0131<\/p>\n

Sigara:<\/strong> Sigara i\u00e7mek, kan testlerinde B12 d\u00fczeylerinin y\u00fcksek \u00e7\u0131kmas\u0131na yol a\u00e7abiliyor.<\/p>\n

\"b12<\/p>\n

The American Journal of Geriatric Psychiatry\u2019de 2021 Nisan ay\u0131ndaki \u00e7al\u0131\u015fmada b12 vitamini y\u00fcksekli\u011finin kan kanseri (hematolojik maligniteler), ba\u011f\u0131\u015f\u0131kl\u0131k sistemi hastal\u0131klar\u0131, bula\u015f\u0131c\u0131 hastal\u0131klar, b\u00f6brek hastal\u0131\u011f\u0131, b\u00f6brek yetmezli\u011fi, kat\u0131 organ t\u00fcm\u00f6rleri ve a\u015f\u0131r\u0131 B12 takviyesi al\u0131n\u0131m\u0131na ba\u011fl\u0131 geli\u015febilece\u011fi yer ald\u0131.<\/p>\n

Clinical Biochemistry’de 2003 Kas\u0131m’da ge\u00e7en incelemeye g\u00f6re, kronik miyeloid l\u00f6semi (bir kan kanseri t\u00fcr\u00fc), promyelositik l\u00f6semi, polisitemi (hemoglobin y\u00fcksekli\u011fi), hipereozinofilik sendrom (beyaz kan h\u00fccresinin \u00e7ok y\u00fcksek seviyede olmas\u0131) ve hematolojik bozukluklar\u0131n b12 y\u00fcksekli\u011fine yol a\u00e7abiliyor.<\/p>\n

\"b12<\/p>\n

Scientific Reports\u2019da Haziran 2021\u2019da yay\u0131nlanan bir di\u011fer \u00e7al\u0131\u015fmaya g\u00f6re de karaci\u011fer hastal\u0131klar\u0131, miyeloid kan maligniteleri, kronik b\u00f6brek yetmezli\u011fi, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi hastal\u0131klar\u0131 veya inflamatuar hastal\u0131klar\u0131, Gaucher hastal\u0131\u011f\u0131 ve aktif solid kanser de b12 y\u00fcksekli\u011fi yapabiliyor.<\/p>\n

B12 \u00c7OK Y\u00dcKSEK OLURSA NE OLUR? B12 Y\u00dcKSEKL\u0130\u011e\u0130 BEL\u0130RT\u0130LER\u0130 NELER?<\/h3>\n

B12 y\u00fcksekli\u011fi, nedenine ba\u011fl\u0131 olarak \u00e7e\u015fitli semptomlara neden olabiliyor. B12 y\u00fcksekli\u011finde g\u00f6r\u00fclen belirtiler \u015f\u00f6yle:<\/p>\n

    \n
  • Yorgunluk, halsizlik<\/li>\n
  • Sinirlilik<\/li>\n
  • Ba\u015f d\u00f6nmesi<\/li>\n
  • Ba\u015f a\u011fr\u0131s\u0131<\/li>\n<\/ul>\n

    \"b12<\/p>\n

      \n
    • Anksiyete<\/li>\n
    • Y\u00fcksek tansiyon<\/li>\n
    • Kas ve eklem a\u011fr\u0131s\u0131<\/li>\n
    • Y\u00fczde k\u0131zarma<\/li>\n
    • Uykusuzluk<\/li>\n
    • Ciltte d\u00f6k\u00fcnt\u00fc<\/li>\n
    • Kar\u0131ncalanma, uyu\u015fma<\/li>\n
    • Kan damarlar\u0131n\u0131n daralmas\u0131<\/li>\n
    • \u00d6dem<\/li>\n
    • So\u011fuk alg\u0131nl\u0131\u011f\u0131 semptomlar\u0131<\/li>\n
    • \u0130drar renginin de\u011fi\u015fmesi<\/li>\n
    • Mide bulant\u0131s\u0131, ishal veya sindirim sorunlar\u0131<\/li>\n
    • Gut alevlenmesi<\/li>\n<\/ul>\n

      \"b12<\/p>\n

      B12 Y\u00dcKSEKL\u0130\u011e\u0130 TEDAV\u0130S\u0130<\/h3>\n

      B12 y\u00fcksekli\u011fi tedavisi bu durumun nedenine ba\u011fl\u0131 olarak de\u011fi\u015fiyor. B12 y\u00fcksekli\u011fi, y\u00fcksek miktarda b12 takviyesi al\u0131m\u0131na yahut b12 i\u00e7eren besinlerin fazla t\u00fcketilmesine ba\u011fl\u0131 geli\u015ftiyse, doktora dan\u0131\u015f\u0131p bunlar\u0131n al\u0131m\u0131 durdurulmal\u0131 yahut s\u0131n\u0131rlanmal\u0131.<\/p>\n

      B12 y\u00fcksekli\u011fi a\u015f\u0131r\u0131 miktarda hayvansal g\u0131da t\u00fcketiminde dolay\u0131 meydana geldiyse bitkisel g\u0131dalara y\u00f6nelmelidir.<\/p>\n

      B12 vitamini suda \u00e7\u00f6z\u00fcnen ve idrarla at\u0131lan bir vitamin oldu\u011fundan bol su i\u00e7meye devam etmeli.<\/p>\n

      Kanserden dolay\u0131 b12 y\u00fcksekli\u011fi g\u00f6r\u00fcld\u00fcyse kemoterapi ve radyo terapi gerekebilir.<\/p>\n

      B12 EN FAZLA KA\u00c7 OLMALI?<\/h3>\n

      Y\u00fcksek B12 d\u00fczeyi genellikle normal aral\u0131\u011f\u0131n \u00fcst s\u0131n\u0131r\u0131ndan (950 pg\/ml’nin ) daha y\u00fcksek bir d\u00fczey olarak tan\u0131mlan\u0131r.<\/p>\n

      B12 Y\u00dcKSEKL\u0130\u011e\u0130 ZARARLARI NELERD\u0130R?<\/h3>\n

      B12 y\u00fcksekli\u011finin en \u00f6nemli zarar\u0131 \u00f6l\u00fcm riskini art\u0131rmas\u0131d\u0131r.<\/p>\n

      \"b12<\/p>\n

      JAMA Network Open\u2019da 2020 Ocak ay\u0131ndaki \u201cHollanda’da Genel N\u00fcfusta Plazma Vitamin B12 Konsantrasyonunun Her T\u00fcrl\u00fc Nedene Ba\u011fl\u0131 \u00d6l\u00fcm Oran\u0131yla \u0130li\u015fkisi\u201d adl\u0131 ortalama ya\u015f\u0131 54 olan 5.571 genel olarak sa\u011fl\u0131kl\u0131 erkek ve kad\u0131n \u00fczerinde yap\u0131lan \u00e7al\u0131\u015fmaya g\u00f6re \u00e7ok y\u00fcksek B12 vitamini seviyelerinin erken \u00f6l\u00fcm riskini art\u0131rd\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n

      Ara\u015ft\u0131rmac\u0131lar, B12 seviyeleri a\u00e7\u0131s\u0131ndan en y\u00fcksek \u00e7eyrekte bulunanlarda \u00f6l\u00fcm oranlar\u0131n\u0131n en d\u00fc\u015f\u00fck \u00e7eyrekte bulunanlara g\u00f6re neredeyse iki kat daha y\u00fcksek oldu\u011funu buldu.<\/p>\n","protected":false},"excerpt":{"rendered":"

      B-12 vitamini(kobalamin), beyin sa\u011fl\u0131\u011f\u0131, k\u0131rm\u0131z\u0131 kan h\u00fccresi \u00fcretimi, sinirlerin d\u00fczg\u00fcn i\u015fleyi\u015fi ve DNA \u00fcretiminde \u00f6nemli rol oynayan, besinlerden veya takviye yoluyla elde edilen bir vitamindir. V\u00fccuttaki b12 vitamin oran\u0131 kan testi yap\u0131larak belirlenebiliyor. Kan testi sonucunda nadiren de olsa b12 vitamini y\u00fcksekli\u011fi g\u00f6r\u00fclebiliyor. <\/p>\n","protected":false},"author":30,"featured_media":98674,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"footnotes":""},"categories":[1991],"tags":[2945],"class_list":["post-98665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-b12-yuksekligi"],"_links":{"self":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/98665"}],"collection":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/comments?post=98665"}],"version-history":[{"count":8,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/98665\/revisions"}],"predecessor-version":[{"id":98718,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/posts\/98665\/revisions\/98718"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/media\/98674"}],"wp:attachment":[{"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/media?parent=98665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/categories?post=98665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tgrthaber.com\/mavikadin\/wp-json\/wp\/v2\/tags?post=98665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}